Golgi Ion Pumps

There is an increasing number of scientific papers dealing with our understanding of Golgi Ion Pumps. Hailey-Hailey Disease appears to be a debilitating manifestation of an underfunctioning Calcium/Manganese ion pump, SPCA1 (ATP2C1). The following abstracts were culled from MedLine from 1999 – 2011. Papers without abstracts are not listed.

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.

Cold Spring Harb Perspect Biol. 2011 May 1;3(5). pii: a004184. doi: 10.1101/cshperspect.a004184. Vandecaetsbeek I, Vangheluwe P, Raeymaekers L, Wuytack F, Vanoevelen J. Source Laboratory of Ca-transport ATPases, Department of Molecular Cell Biology, K.U. Leuven, Leuven, Belgium. Abstract The various splice variants of the three SERCA- … Read More

Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors inHailey-Hailey and Darier epidermis.

J Invest Dermatol. 2009 Jun;129(6):1379-87. doi: 10.1038/jid.2008.381. Epub 2008 Dec 4. Leinonen PT, Hägg PM, Peltonen S, Jouhilahti EM, Melkko J, Korkiamäki T, Oikarinen A, Peltonen J. Source Department of Anatomy and Cell Biology, Institute of Biomedicine, University of Oulu, Oulu, Finland. pekka.t.leinonen@oulu.fi Abstract Electron probe microanalysis was … Read More

Autosomal-dominant calcium ATPase disorders.

J Invest Dermatol. 2006 Nov;126(11):2370-6. Epub 2006 Jun 22. Szigeti R, Kellermayer R. Source 1Department of Dermatology, University of Pécs, Pécs, Hungary. Abstract Darier disease (DD) and Hailey-Hailey disease (HHD) are the only known autosomal-dominant Ca2+ ATPase disorders. Epidermal symptoms selectively occur in the … Read More

The Ca2+/Mn2+ pumps in the Golgi apparatus.

Biochim Biophys Acta. 2004 Dec 6;1742(1-3):103-12. Van Baelen K, Dode L, Vanoevelen J, Callewaert G, De Smedt H, Missiaen L, Parys JB, Raeymaekers L, Wuytack F. Source Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000, Leuven, Belgium. Abstract Recent evidence highlights the functional importance of the … Read More

Calcium pump disorders of the skin.

Am J Med Genet C Semin Med Genet. 2004 Nov 15;131C(1):20-31. Foggia L, Hovnanian A. Source Department of Medical Genetics, Pavillon Lefebvre, Purpan Hospital, Place du Dr Baylac, Toulouse cedex 03, France. Abstract The causes of Darier disease (DD) and Hailey-Hailey disease … Read More

SPCA1 pumps and Hailey-Hailey disease.

Biochem Biophys Res Commun. 2004 Oct 1;322(4):1204-13. Missiaen L, Raeymaekers L, Dode L, Vanoevelen J, Van Baelen K, Parys JB, Callewaert G, De Smedt H, Segaert S, Wuytack F. Source Laboratorium voor Fysiologie, K.U.Leuven Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Abstract Both the endoplasmic reticulum and the Golgi apparatus … Read More