Hailey-Hailey disease: a widespread abnormality of cell adhesion.

Br J Dermatol. 1991 Apr;124(4):329-32.


Department of Dermatology, Slade Hospital, Oxford, U.K.


Suction has been used to investigate cell adhesion in clinically normal skin in Hailey-Hailey disease. We have demonstrated that there is a widespread subclinical abnormality in keratinocyte adhesion in this disease. There may be a synthesis of functionally deficient adhesion junctions, increased breakdown of adhesion junctions or abnormalities in other adhesion proteins in the epidermis in Hailey-Hailey disease. The findings contrast with those in Darier’s disease in which abnormal cell adhesion was only demonstrable in clinically involved skin.

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