Bacterial infection-induced generalized Hailey-Hailey disease successfully treated by etretinate.

Clin Exp Dermatol. 2006 Jan;31(1):57-9.


Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.


Hailey-Hailey disease (HHD; familial benign chronic pemphigus) is a hereditary blistering disorder characterized by episodic maceration and erosions mainly in intertriginous areas, and generalized eruptions are rarely seen. We report here a 51-year-old woman with generalized HHD who was successfully treated with oral etretinate. The present case suggests that oral etretinate is effective against the generalized eruptions even in cases in which bacterial infection has triggered the generalization of HHD.

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