Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease.

J Dermatolog Treat. 2008;19(4):251-4. doi: 10.1080/09546630801955135.


Catharina Hospital Eindhoven, Eindhoven, The Netherlands.



Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed.


To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease.


The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport was started in all six cases.


Marked improvement of the lesions was achieved with few side effects in all patients.


Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.

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