Squamous cell carcinoma arising from a localized vulval lesion of Hailey-Hailey disease after tacrolimus therapy.

Am J Obstet Gynecol. 2010 Sep;203(3):e5-7. doi: 10.1016/j.ajog.2010.06.041.


Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany. vvonfelbert@ukaachen.de


Hailey-Hailey disease (HHD) is a rare, autosomal dominant intraepidermal blistering disorder characterized by recurrent vesicles and erosions affecting mostly the intertriginous areas. We report a case of HHD affecting exclusively the vulva from which an invasive squamous cell carcinoma developed after tacrolimus therapy.

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